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The dosing framework on this page is based on the published Phase 2 trial (Jastreboff et al., 2023, NEJM ) and the Rosenstock et al
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In functional B2 deficiency, the child has reduced capacity to gain energy from fats, as the reductase is FAD-dependent, or to gain energy from sugar, due to the need of pyruvate decarboxylase for TPP, lipoate and FAD
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Published December 29, 2022
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