23 April 2025 A Correction to this paper has been published: Abbreviations BBB: Bloodbrain barrier CNS: Central Nervous System GFAP: Glial fibrillary acidic protein GLP-1R: Glucagon-like peptide-1 receptor HFD: Highfat diet IB4: Biotinylated isolectin B4 Iba-1: Ionized calciumbinding adaptor molecule-1 ND: Normolipid diet NVU: Neurovascular unit SAL: Saline solution SEMA: Semaglutide References Grundy SM, Brewer HB, Cleeman JI, Smith SC, Lenfant C
For those who have encountered similar symptoms with approved GLP-1 agents prescribed by their GP, a routine appointment is appropriate if symptoms are persistent or troublesome
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In human fibroblast cultures, this has been shown to extend the "Hayflick limit" (the number of times a cell can divide) by over 10 passages
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