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Strategies for breaking through Dose adjustment is the most direct pharmacological approach

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100, 137 The G-protein-coupled Mas receptor was reported to mediate some of the effects of Ang-(17)

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The enzymatic complex superoxide dismutase (SOD) and Reduced nicotinamide adenine dinucleotide phosphate- oxidase (NADPH-oxidase, specifically, the NOX4 isoform localized in the mitochondria) have been identified as the main source of H 2 O 2 ( 2 O 2 production by SOD activity leads to an early inhibition of EAS enzymes activity such as TrxR (Schallreuter et al., 1991a), CAT and GPx, which in turn, leads to an increase in Fenton reaction, increasing hydroxyl concentrations (Fe 2+ + H 2 O 2 Fe 3+ + OH + OH) to a toxic level, that ultimately, leads to a significant peroxidation in several cellular components (membranes, proteins, mitochondria, and DNA) (Schallreuter, 2014)

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