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Together with still prominent lymphocytic infiltration and inflammation in progressive MS, being particularly pronounced in the meninges and perivascular spaces, leads some investigators to conclude that inflammation primarily drives demyelination and degeneration at all stages of this disease (Lassmann, 2018)

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doi:10.1111/j.1365-2125.1984.tb02547.x

Neonatal presentation includes hepatosplenomegaly, bleeding diathesis, abnormal liver function, cholestatic jaundice, and elevated liver function enzymes

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