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Methodological Quality and Risk of Bias Assessment We used the Cochrane Risk of Bias 2 (RoB 2) tool (crossover extension where applicable) for assessing the risk of bias to evaluate the methodological quality of RCTs

181 Diffuse traumatic brain injury Diffuse (also known as mild) TBI results from the action of acceleration or deceleration forces on the head, which leads to a strain and concussion of the brain tissue

Blockages from hardened stool, foreign bodies, or infections can cause appendicitis by allowing bacteria to multiply, leading to inflammation and infection

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However, those studies measured total drug exposure over time, not the timing and peak concentration of hormone delivery, which is what matters most for contraceptive reliability