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The binding of autotaxin to integrins mediates hyperhomocysteinemia-potentiated platelet activation and thrombosis in mice and humans

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Additionally, the NNMT substrate nicotinamide 12 is metabolized by the microbiome 56,57 , and thus NNMTi may modulate substrate availability, potentially influencing microbial metabolic capacity to drive the NNMTi-mediated weight loss

In particular, D10-containing (10% sugar) IV fluids may be helpful if given early, although this is not always available and D5-containing fluids at high rates can be substituted

Available at: (Accessed: 21st July 2015) (2000)