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The medication should be discontinued when pregnancy is recognized or before planned conception

Oral routes are preferred only when local GI action is the goal, when the molecule is engineered for oral stability, or when the peptidomimetic structure resists digestion

In selected situations, a patient and healthcare provider may discuss: These biomarkers may provide a broader picture of lipid oxidation, inflammatory-enzyme activity, or antioxidant status

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The electronic search encompassed a number of databases, including PubMed, MEDLINE, Embase, Web of Science, and Reprotox, covering the period from database inception through January 2026