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The skin-lightening effect mainly occurs due to the inactivation of the enzyme Tyrosinase, which activates the melanin pigment

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Mechanism understanding helps troubleshooting non-responders, switching to peptides targeting different pathways potentially more relevant for specific individual pathophysiology

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(4) Peter J Apel, Jian Jun, Michael Callahan, Casey N Northam, et al (2010) Effect of Locally Delivered IGF-1 on Nerve Regeneration During Aging: An Experimental Study in Rats Muscle Nerve, 2010 Mar, Volume 41 (Issue 3), Pages 335341