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Funding This work is supported by a research grant from the Jinzhou Science and Technology Bureau (Grant Number: JZ2022B039)
Carnitine transporter mutations in Crohn's disease consists of missense mutation(s) in the gene coding plasma membrane transporter OCTN1 (SLC22A4) and/or mutation(s) in the promoter of the gene encoding OCTN2 (SLC22A5) [14, 35]
As we age, NAD+ levels decline, which contributes to fatigue, cognitive changes, and visible signs of aging
Without adequate levels, this conjugation process stalls, and hormone byproducts can recirculate instead of being cleared
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