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Thus, long-term data on the safety in adolescents is limited, particularly regarding the risks of cholelithiasis, pancreatitis, suicidal ideation, and disordered eating [31]

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Zinc, which is essential for the formation of myelin and can induce oxidative stress in its own right, may be involved in the abnormal homeostasis of bioactive metals, which might play a role in Alzheimer's disease - zinc binds to amyloid precursor protein 57 and aluminium, zinc, iron, and copper directly bind to amyloid protein promoting its aggregation

Harborne, J.) 120 (Springer, 1988)

A 2017 meta-analysis found no significant increase in pancreatitis or pancreatic cancer risks (odds ratios 0.93 and 0.94, respectively)