Semaglutide can do something very few drugs can: lower weight, improve blood sugar, and reduce cardiovascular risk all at once
Serva SN, Bernstein J, Thompson JA, Kern DS, Ojemann SG
Phase 2 Clinical Trial Data The landmark Phase 2 trial of retatrutide in obesity was a 48-week, randomized, double-blind, placebo-controlled study published in The New England Journal of Medicine in 2023
However, combined exposure resulted in unexpectedly lower toxicity than either pollutant alone
(2021) of the CVOTs found that the GLP-1 RAs are associated with a significant 14% relative risk reduction in terms of major adverse cardiovascular events (MACE, a standard 3-component composite endpoint) (hazard ratio [HR] 0.86