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Annals of Neurology, 36(3), 356-361
What kind of studies would you design for each
Even the lower dosage groups, such as 4 mg, demonstrated measurable improvements in fasting glucose, insulin resistance, and HbA1c
SGLT2 inhibitors In people with type 2 diabetes, cardiovascular outcome trials (CVOTs) with empagliflozin, canagliflozin and dapagliflozin have established that use of these SGLT2 inhibitors reduces the risk of CV events (quantified as a composite of non-fatal myocardial infarction, non-fatal stroke and CV death) versus placebo in: Established atherosclerotic CV disease (ASCVD
Therefore, this review aims to synthesize the evidence on the mechanistic expansion of GLP-1RAs from metabolic regulators to systemic modulators of inflammation, autophagy, and organ protection, and explores their therapeutic repurposing across diseases
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