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The UK Government wants to reduce the inequalities gap between those who are having to wait for these drugs on the NHS versus those who can afford to access them privately

Biochim Biophys Acta 1780:638651

Acute Effect of a Saffron Extract (SafrInsideTM) and Its Main Volatile Compound on the Stress Response in Healthy Young Men: A Randomized, Double Blind, Placebo-Controlled, Crossover Study

It is worth remembering that they are subjective and can be influenced by expectations, simultaneous changes in training or diet, and by each persons starting point