Figure 3 3.4 Epigenetic and signal transduction effects The regulation of epigenetics and the manipulation of signal transduction pathways have emerged as a fundamental mechanistic basis by which natural agents can exert strong anti-cancer effects in breast cancer, affecting the various stages of tumour development (initiation, progression, metastasis), and response to therapy by targeting diverse interactions between gene expression, chromatin structure, and intracellular signalling elements (198)
Cakir-Kiefer, C., Muller-Steffner, H., Oppenheimer, N
Copper in its metallic state has no effect on the skin and it becomes a potential irritant or allergen when it is corroded to become soluble through the action of exudates encountered on the skin surface, or in a relatively corrosive physiological environment such as the oral cavity or the uterus 3
Dung dch cn t yu cu tan hon ton trong nc ct, ch phm thu c phi trong sut, khng mu
10.1124/jpet.106.100982