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Even people who achieve the treatment goals with the new obesity pharmacotherapies might decide to undergo bariatric surgery to support long-term weight maintenance because either they experience weight regain on the medication or they do not have long-term access to obesity pharmacotherapy, or they prefer not to take obesity pharmacotherapy lifelong

Other side effects, though may get a lot of media attention, are doubtful based on the current evidence from thousands of patients in clinical trials

If you think of all the possible mechanisms, across GLP-1, GIP, amylin, and even cannabinoid receptors, you get a giant Venn diagram of overlapping options

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Both agents affect appetite signaling and metabolic pathways, raising concerns about additive effects and unpredictable outcomes