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2) Administration of a combination of cagrilintide and semaglutide resulted in significant weight loss, as well as reductions in HbA1c levels in type 2 diabetic participants

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doi: 10.1016/S0006-2952(03)00504-5 20

This is also where most of the controversy lies: Injections: This is the fastest-acting and most potent route, but it carries serious risks including allergic reactions, infections, kidney or thyroid damage, toxicity and ochronosis