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Importantly, Hinton and colleagues showed that human IgG2 variants harboring Fc fragments with amino acid substitutions that increase their binding affinity towards human FcRn at specifically pH 6.0, but not pH 7.4, had prolonged plasma half-lives in non-human primates (NHPs) [104]

Mechanism, Depth, Biology Here is the molecule, the receptor biology, and the gene-expression data in one place, as primary-sourced as we can make it without turning the section into a review article

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