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However, in mammals, they become much more prominent, being separated from the jaws by a deep cleft (a notable exception being the naked mole-rat, whose lips close behind the front teeth)

In February 2026, full results from the REDEFINE 2 study showed CagriSema achieving 23% weight loss at 84 weeks but falling short of its primary endpoint under the treatment policy estimand (which measures efficacy across all patients regardless of whether they completed treatment, rather than only those who remained on it)

Deb P, Chini A, Guha P, Rishi A, Bhan A, Brady B, Perrotti LI, Mandal SS

Note that the nurses were advised accordingly rather than being asked their professional opinion as the frontline workers

(2017, September 12)