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Asymptomatic gallstones generally allow continued tirzepatide use with monitoring, while symptomatic gallstones require gastroenterology referral and clinical judgment about temporarily holding the medication

Do not make assumptions about safety Exceeded in-use storage period Discard the pen according to local waste disposal guidelines for sharps and medications Clinical implications of using degraded medication may include inadequate glycaemic control in diabetes management or reduced weight loss efficacy

however, losing weight (and maintaining weight loss) through diet and exercise alone is challenging

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