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7 In 1993, a German laboratory confirmed what Engs paper had implied: exendin-4 was not merely structurally similar to GLP-1 it was a high-potency agonist at the human GLP-1 receptor, stimulating the same cAMP signaling cascade in insulin-secreting beta cells and amplifying glucose-induced insulin secretion
Temporary holding of GLP-1 RAs is controversial, as it is unsupported by data regarding optimal washout for return of normal gastric emptying and could increase the risk of glycemic instability [12]
Sermorelin, by contrast, is available and commonly prescribed
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Incretins modulate pancreatic islet secretions as part of the "entero-insular axis," and their primary function is to regulate postprandial nutrient utilization and storage
