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Of note, incidence of MTC was extremely low in all of the large cardiovascular outcome trials with no significant increase seen in GLP-1RA-treated individuals, although it should be highlighted that some of the trials did have a family history of MEN-2 as an exclusion criterion
Assay of glutathione, glutathione disulfide, and glutathione mixed disulfides in biological samples
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Causality was assessed with the Naranjo scale, which calculated a score of four, indicating a possible drug reaction (Table 2) [9]
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