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An essential role for monocyte chemoattractant protein-1 in alcoholic liver injury: regulation of proinflammatory cytokines and hepatic steatosis in mice

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We found that blocking the translation of NRF2 prevented GSH accumulation ( Figure 7F ) as well as negated the immunosuppressive action of melatonin treatment ( Figures 7H, I )

The two pathways converge on somatotroph calcium signaling but engage different second-messenger cascades, which is why the combination can produce more GH than either agent alone