HDAC6 inhibitor Ricoliostat: HDAC6 inhibitors can promote the degradation of protein aggregates or protect neurons from oxidative stress, hence can be used as possible drugs for treating peripheral neuropathy
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Similarly, IRE1 dysregulation has been observed in tauopathies, PrD, and HD, highlighting its role in neurotoxicity, whereas ATF6 dysfunction exacerbates protein aggregation and has been linked to FTD and tauopathies
Brattstrm L, Landgren F, Israelsson B, Lindgren A, Hultberg B, Andersson A, Cuskelly G, McNulty H, Strain SS, McPartlin J, Weir DG, Scott JM, den Heijer M, Brouwer IA, Blom HJ, Bos GMJ, Spaans A, Rosendaal FR, Thomas CMG, Haak HL, Wijermans PW, Gerrits WBJ, Naurath HJ, and Joosten E (1998)
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