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These intermediate substances interfere with mitochondrial function, cause oxidative stress, and initiate apoptosis

Indeed, patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and AxSpA exhibit increased rates of systemic osteoporosis and osteoporotic fractures

Fatal outcomes documented : First fatal case at therapeutic doses in a woman with intrahepatic cholestasis

Women who are not planning to become pregnant might want to use backup barrier methods or switch to non-oral contraceptive options, such as patches, rings, or IUDs, particularly during the first few weeks after a dose increase