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Semaglutide (Wegovy) and tirzepatide (Zepbound) have received FDA approval for chronic weight management in adults with a BMI 30, or 27 with at least one weight-related comorbidity, when used alongside diet and exercise
Much of the current research comes from animal and laboratory studies, so findings are still emerging
Gopal Grandhige, MD, FACS, Board-Certified Surgeon Last Reviewed: June 5, 2026 MOTS-C can be stacked with several other peptides, and the pairings that hold up best are the ones built on completely different biological mechanisms