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At least one study showed that an acute injection of trimetazidine (10 mg/kg) reduced hippocampal inflammation measured by TNF- and IL-1 while protecting against seizure and associated cognitive impairments in diabetic and epileptic rats [161]
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The dissected brains were incubated in 100 nM TMRE solution (Thermo Fisher Scientific) in DSM for 10 min and relative fluorescence intensity was quantified by top excite-read method through Synergy H1 reader
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