Available at: Younossi ZM, Kalligeros M, Henry L
When you look closely at the evidence, youll find that the risks associated with this unregulated peptide often outweigh its unproven claims
Regulatory oversight is evaded as anonymous vendors and some functional medicine practitioners illegally prescribe these untested agents
Great for: supporting energy production & metabolism, psychological function, red blood cell production
The key milestones include: exenatide approval (2005), liraglutide approval (2010), semaglutide injection approval (2017), oral semaglutide with SNAC approval (2019), orforglipron cryo-EM structure published (2020), orforglipron Phase 2 results in NEJM (2023), orforglipron Phase 3 ATTAIN-1 results in NEJM (2025), and FDA regulatory submission (2025)