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McCoin CS, Knotts TA, Ono-Moore KD, Oort PJ, Adams SH

Using lower doses with comprehensive support actually reduces risk

Individuals with a history of medullary thyroid cancer, multiple endocrine neoplasia syndrome type 2, or those who've experienced pancreatitis or severe gastrointestinal diseases should discuss alternatives with their provider

The good news is that oral semaglutide holds its own

Plateaus on GLP-1 therapy happen for a few predictable reasons: your dose needs to go up, your body has adapted to your current medication, or there's a metabolic factor (thyroid, insulin resistance, cortisol) that bloodwork would reveal and guesswork won't