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Se han identificado GLP-1R en el ndulo sinoauricular, miocitos auriculares y ventriculares y endotelio vascular, cuya activacin genera efectos antiinflamatorios, reductores del estrs oxidativo y antiaterognicos, que sustentan los efectos cardioprotectores y nefroprotectores de los agonistas de GLP-1 (fig
& Chan, K
Tirzepatide was approved largely based on data from the SURPASS series of clinical trials
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