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Methods Islets were isolated from wild-type (WT), Gipr -knockout ( Gipr / ), Gcgr -knockout ( Gcgr / ), Glp-1r (also known as Glp1r )/ Gipr double-knockout and Trpm5 -knockout ( Trpm5 / ) mice, followed by assessment of beta cell function and insulin secretion in response to mono- and multi-agonist administration

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No published receptor binding constant or characterised minimum effective concentration anchors the dose, so dose decisions rest on preclinical envelopes. TB-4: cell migration What it is TB-4 is a naturally occurring 43-amino-acid peptide involved in cell movement and tissue repair

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