Daver NG, Assi R, Kantarjian HM, Cortes JE, Ravandi F, Konopleva MY, Kadia TM, Borthakur G, Jabbour EJ, DiNardo CD, Velasquez M, Kelly M, Ning J, Nogueras Gonzlez GM, Pierce SA, Gombos D, Estrov ZE, Kornblau SM, Zhang W, Andreeff M
Tsvetkov P, Coy S, Petrova B et al (2022) Copper induces cell death by targeting lipoylated TCA cycle proteins
It also promotes liver detoxification
In cautious research discussion, no the emphasis is on titrating each compound independently and slowly, never pushing both to maximum simultaneously, because the combination has never been tested for safety in humans
The increase in SAH levels is sufficient for sensitizing the liver and hepatocytes to tumor necrosis factor (TNF) cytotoxicity