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Mice were randomized to one of the four treatment groups (n = 10/group) based on body weight and 6 h-fasted glucose measured on day -4: control antibody (10 mg/kg), MEDI4166 (10 mg/kg) or Ab#2.1_EX4 (10 or 30 mg/kg)

We've worked with patients across every protocol variation

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Similarly, it should be used with caution in patients with a history of urinary retention, angle-closure glaucoma, or increased intraocular pressure, as it can exacerbate these conditions