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Wegovy evidence in prediabetes STEP 10: the dedicated prediabetes trial STEP 10 was a 52-week randomised, double-blind, placebo-controlled trial in 207 people with obesity and prediabetes, conducted across Canada, Denmark, Finland, Spain, and the UK and led by Professor Barbara McGowan at Guys and St Thomas NHS Foundation Trust
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We performed this subgroup analysis for two reasons: 1) to eliminate the potentially confounding factor of using other diabetic medications such as metformin or insulin, and 2) we did not have data on the severity of diabetes such as hemoglobin A1c which may be an additional confounding factor
Plasma levels of GHK are estimated at around 200 ng/mL at age 20 and decline steadily with age, which coincides with the slowdown in collagen production and wound repair that characterizes aging skin
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