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GLP-1 RAs approved by the US Food and Drug Administration (FDA) for T2DM and obesity (semaglutide, exenatide, liraglutide, tirzepatide, dulaglutide) were included in the analysis

Laboratory studies investigate how this peptide influences energy expenditure models, substrate utilization, and systemic metabolic responses

Thau, L., Gandhi, J., & Sharma, S

A 2024 study in dexamethasone-induced NASH rats demonstrated that L-carnitine restored Akt phosphorylation, inhibited FOXO1 nuclear translocation, and downregulated autophagy and apoptosis markers (LC3, P62, caspase-3, p-MLKL) via the Akt/FOXO1 pathway (59)

8 To date, all these peptides have followed similar trajectories: promising animal data with no evidence of efficacy in humans, despite extensive advertising and widespread availability of these compounds to athletes