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This interaction helps explain both its vascular effects and its apparent benefits for various organ systems beyond musculoskeletal tissues
Research demonstrates that collagen peptides working through TGF-/Smad3 pathway activation can reduce MMP-3, MMP-13, MMP-2, and MMP-9 activity while increasing procollagen synthesis, attenuating the collagen degradation characteristic of photoaged skin
So when a medic says that someone with PA "can use the stored B12 in their liver", as far as I know, we simply don't know whether this is true or not
This receptor-binding mechanism forms the foundation of how peptide signaling works
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