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It was a setback, but as it often happens in science, it was not the end of the road for AOD-9604, paving the way for a new and unexpected chapter in its story

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At the molecular level, reduced NNMT activity shifts cellular methylation patterns, potentially altering epigenetic modifications via changes in SAM/S-adenosylhomocysteine (SAH) ratios

Similarly, in the current study, DIO mice from both groups that were switched from WD to LD exhibited higher Bacteroidetes and significantly lower Firmicutes relative abundances compared to DIO mice maintained on WD (WD controls