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Healthy cells do not lean on the FOXO4-p53 link for survival, which is why the effect is reported as selective for senescent cells
In addition, there is a likely analogy (see for review i.e., (Seiwerth et al., 2018)) with the attenuated fibrosis and scar formation in other tissues (i.e., the skin, muscle, tendon, and ligament) (Mikus et al., 2001
Research has shown potential benefits for tendon and ligament repair, muscle recovery, gastrointestinal conditions such as leaky gut and inflammatory bowel issues, and even neuroprotective effects
40% risk reduction for composite of 🏥 for 🫀 failure or all-cause ☠️⚰️ vs" loading="lazy"/>
