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Cyanocobalamin produces trace amounts of free cyanide during metabolism, and while this is clinically insignificant in people with normal kidney function, impaired renal clearance could theoretically allow accumulation

Mohandes S, Doke T, Hu H, Mukhi D, Dhillon P, Susztak K (2023) Molecular pathways that drive diabetic kidney disease

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Evaluation of oral health status and influential factors in children with autism

Available as a once-weekly injection, it is suitable for adults with a BMI of 30 or higher, or 27 or greater with a related health condition like hypertension