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This genetic complexity of human diseases limits the broad application of gene editing therapies, except for well-known diseases caused by mutations of a single gene, like sickle cell anemia 14
The splicing mutant of the human tumor suppressor protein DFNA5 induces programmed cell death when expressed in the yeast Saccharomyces cerevisiae
Mannervik B, Castro VM, Danielson UH, Tahir MK, Hansson J, Ringborg U
"Look, you see cooked shrimp is under those items," she says
In other cases, receptor families were poorly understood, leading to concerns about cross-reactivity or unintended signaling
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