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The FDA-approved prescribing information recommends gradual dose titration to minimize gastrointestinal side effects, typically starting at 2.5 mg weekly and increasing in 2.5 mg increments every 4 weeks as tolerated

Lawrence Herman: Served on an advisory board for Novo Nordisk and is on the speakers bureau for Novo Nordisk

Recent analyses presented at the National Lipid Associations 2025 Scientific Sessions highlighted cardiovascular, renal, and metabolic gains from GLP1s that appear partly independent of the amount of weight loss

The side effects from tirzepatide overdose can be debilitating and may require IV fluids

In the context of erythrocyte death, several enzymatic activities have been described to be involved in sphingomyelin breakdown: (i) cigarette smoke extracts (CSEs) elicit neutral SMase activity-dependent erythrocytic ceramide formation [130]