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Interestingly, the inhibitor CPD-3B is virtually non-toxic to normal cells, while targeting not only GLS1 and GDH but also thioredoxin reductase (TrxR) and amidotransferase (GatCAB), resulting in the selective elimination of cancerous cells through a multifaceted mechanism

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CIRBP, a protein that promotes ferroptosis under cold stress, is downregulated in PDAC tissue compared with adjacent normal tissues [104]

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