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Clinical Evidence and Scientific Studies A landmark 2023 study published in the Journal of the American Medical Association revealed alarming statistics about the gastrointestinal risks associated with GLP-1 receptor agonists like Ozempic, particularly when used for weight loss purposes

This is both evidence that treatments such as SGLT-2is and GLP-1RAs should not be modelled as continuing indefinitely, and that model results which predict longer adherence to semaglutide are supported by real world evidence

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