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The Pyruvate Dehydrogenase complex oxidizes pyruvate produced by glycolysis to acetyl-CoA, and is a major control point of TCA cycle activity for carbohydrate metabolism (Gray, Tompkins, & Taylor, 2014)
This approval validated its mechanism of action and established its legitimacy as a medical treatment
The practical risk for patients is real
Retatrutide is a weekly injectable weight loss medication currently being developed by Eli Lilly (the same company that makes Mounjaro) for the treatment of type 2 diabetes and obesity
In real-world data, the average 3-month weight loss was 5.9% for tirzepatide versus 3.6% for semaglutide
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