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It is characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture

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442 Future progress will require coordinated breakthroughs in high-specificity clonal tracking, multiomicsbased mechanistic analysis, prospective clinical validation, and standardized workflow development for liquid biopsy to become a key tool in guiding strategies to overcome therapeutic resistance

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