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However, if the water has been opened or exposed to air for a prolonged period of time, it may deteriorate more quickly and need to be replaced sooner than two years
Therefore, non-significant findings should be considered inconclusive rather than indicative of no treatment effect, and future studies with larger cohorts are warranted to clarify these observations
Two estimands were employed: the trial product estimand, which evaluated treatment effects assuming perfect adherence to the assigned regimen, and the treatment policy estimand, which included all randomized participants regardless of adherence
Cherney K
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