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The increase correlates directly with the launch of high-efficacy GLP-1 medications (Wegovy in 2021, Mounjaro and Zepbound in 2022-2023) and the associated cost pressure on plan sponsors

In recent years, there has been an increase in the morbidity, disability rate,and mortality due to obesity, making it great threat to peoples health and lives, and increasing public health care expenses

Initial loss in the first 4 weeks comes mostly from gastric effects

During the first 4 h after LPS administration, the percentage of monocytes ( Figure 2F ) decreased by 90% with a large animal-specific variation to the mean nadir, followed by a slight increase until the end of the study