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Acknowledgements The authors would like to thank Thomas Rohban, MD, and Magalie El Hajj, PharmD, from Partner 4 Health (Paris, France) for providing medical writing support in accordance with Good Publication Practice (GPP3) guidelines

The scope of the review is intentionally selective rather than exhaustive, focusing on peptidereceptor systems that demonstrate biological plausibility, mechanistic coherence, and unmet therapeutic potential, yet lack approved therapeutic analogs or advanced clinical programs

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