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Additionally, dimerization can stabilize proteins, helping them maintain their functional conformation and resist denaturation under physiological conditions as well as regulate intracellular signaling molecules 9,10

& Kayano, T

While the drug remains effective in regions where DHFR mutations have not fully compromised its activity, its vulnerability to resistance highlights the need for ahit hard and early approach to minimize resistance development

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Research-grade somatropin follows the same physical rules but relies on general protein behavior rather than regulatory validation