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Store the prepared nasal spray in the fridge, upright, for up to six months

These medications mimic a natural hormone in the body that helps regulate blood sugar, digestion, and appetite

Dose-dependent effects of mandibular advancement on upper airway collapsibility and muscle function in obstructive sleep apnea

It notes that mild to moderate hepatic or renal impairment may prolong drug exposure, and that age-related decline in kidney function can slow clearance, particularly in patients over 65