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This dual localization dictates a bifurcated immunological outcome: Peroxisomal MAVS (pexMAVS) orchestrates a rapid, transient, and Type I interferon-independent induction of interferon-stimulated genes (ISGs, such as Viperin), whereas mitochondrial MAVS (mitoMAVS) coordinates a delayed, stable Type I interferon (IFN-/) response
Liu et al., 2021
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This is the problem DSIP targets directly
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